@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix skos:  <http://www.w3.org/2004/02/skos/core#> .
@prefix itsrdf: <http://www.w3.org/2005/11/its/rdf#> .
@prefix nif:   <http://persistence.uni-leipzig.org/nlp2rdf/ontologies/nif-core#> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context>
        nif:beginIndex    "0"^^xsd:nonNegativeInteger ;
        nif:endIndex      "2557"^^xsd:nonNegativeInteger ;
        nif:firstSection  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=0,247> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610> ;
        nif:hasSection    <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2451,2462> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2464,2557> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=0,247> ;
        nif:isString      "Mipomersen (previously ISIS 301012, trade name Kynamro) is a cholesterol-reducing drug. It is an antisense therapeutic that targets the messenger RNA for apolipoprotein B. It is administered as a weekly injection for familial hypercholesterolemia.\n\nIndications\nKynamro is FDA approved to treat homozygous familial hypercholesterolemia (HoFH). It reduces LDL-C, non HDL-C, and apolipoprotein B. Over a 26-week trial LDL decreased 25%. The FDA decided on a boxed warning of liver toxicity and requires cerfiication by the prescriber and pharmacy. Mipomersen decreases hepatic and plasma apoB as well as apoC-III.\n\nChemical properties\nThe compound is a 'second-generation' antisense oligonucleotide; the nucleotides are linked with phosphorothioate linkages rather than the phosphodiester linkages of RNA and DNA, and the sugar parts are deoxyribose in the middle part of the molecule and 2'-O-methoxyethyl-modified ribose at the two ends. These modifications make the drug resistant to degradation by nucleases, allowing it to be administered weekly. The drug accumulates in the liver, which is convenient since apolipoprotein B predominantly acts there. The complete sequence is <a href=\"/mediawiki/index.php?title=Guanosine_monophosphate\" title=\"Guanosine monophosphate\">G</a>*-<a href=\"/mediawiki/index.php?title=Cytidine_monophosphate\" title=\"Cytidine monophosphate\">C</a>*-C*-<a href=\"/mediawiki/index.php?title=Uridine_monophosphate\" title=\"Uridine monophosphate\">U</a>*-C*-d<a href=\"/mediawiki/index.php?title=Adenosine_monophosphate\" title=\"Adenosine monophosphate\">A</a>-dG-d<a href=\"/mediawiki/index.php?title=Thymidine_monophosphate\" title=\"Thymidine monophosphate\">T</a>-dC-dT-dG-d<a href=\"/mediawiki/index.php?title=5-Methylcytidine_monophosphate\" class=\"mw-redirect\" title=\"5-Methylcytidine monophosphate\">mC</a>-dT-dT-dmC-G*-C*-A*-C*-C* [d = 2'-deoxy, * = 2'-O-(2-methoxyethyl)] with 3'→5' phosphorothioate linkages.\n\nClinical development\nThe drug was discovered and developed to Phase 2 by ISIS Pharmaceuticals and subsequently licensed to Genzyme Corporation in 2008 by an auction bid. Isis earned an upfront payment of $325 million, with payments of a further $825 million if milestones are met. In January 2013, The United States Food and Drug Administration approved mipomersen for the treatment of homozygous familial hypercholesterolemia. Launch quantities will be manufactured by Isis at their Carlsbad manufacturing facilities.\n\nReferences\n\n\nExternal links\n\n* Phase III trials of Mipomersen \n* Phase 3 results from Isis Pharmaceuticals" ;
        nif:lastSection   <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2464,2557> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=0,247> ;
        nif:predLang      <http://lexvo.org/id/iso639-3/eng> ;
        nif:sourceUrl     <http://en.wikipedia.org/wiki/Mipomersen?oldid=723546647> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=title&char=2451,2461>
        a                     nif:Title ;
        nif:anchorOf          "References" ;
        nif:beginIndex        "2451"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2461"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2451,2462> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=1110,1126>
        a                     nif:Phrase ;
        nif:anchorOf          "apolipoprotein B" ;
        nif:beginIndex        "1110"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1126"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Apolipoprotein_B> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=title&char=612,631>
        a                     nif:Title ;
        nif:anchorOf          "Chemical properties" ;
        nif:beginIndex        "612"^^xsd:nonNegativeInteger ;
        nif:endIndex          "631"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=2343,2383>
        a                     nif:Phrase ;
        nif:anchorOf          "homozygous familial hypercholesterolemia" ;
        nif:beginIndex        "2343"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2383"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2212,2449> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Familial_hypercholesterolemia> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=title&char=2464,2478>
        a                     nif:Title ;
        nif:anchorOf          "External links" ;
        nif:beginIndex        "2464"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2478"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2464,2557> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2479,2557>
        a                     nif:Paragraph ;
        nif:beginIndex        "2479"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2557"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2464,2557> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610>
        a                     nif:Section ;
        nif:beginIndex        "249"^^xsd:nonNegativeInteger ;
        nif:endIndex          "610"^^xsd:nonNegativeInteger ;
        nif:hasParagraph      <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=261,544> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=545,610> ;
        nif:lastParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=545,610> ;
        nif:nextSection       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        skos:notation         "1"^^<http://www.w3.org/2000/01/rdf-schema#Literal> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1952,2211>
        a                     nif:Paragraph ;
        nif:beginIndex        "1952"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2211"^^xsd:nonNegativeInteger ;
        nif:nextParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2212,2449> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=2080,2099>
        a                     nif:Phrase ;
        nif:anchorOf          "Genzyme Corporation" ;
        nif:beginIndex        "2080"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2099"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1952,2211> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Genzyme_Corporation> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=376,392>
        a                     nif:Phrase ;
        nif:anchorOf          "apolipoprotein B" ;
        nif:beginIndex        "376"^^xsd:nonNegativeInteger ;
        nif:endIndex          "392"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=261,544> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Apolipoprotein_B> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2451,2462>
        a                     nif:Section ;
        nif:beginIndex        "2451"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2462"^^xsd:nonNegativeInteger ;
        nif:nextSection       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2464,2557> ;
        nif:previousSection   <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        skos:notation         "4"^^<http://www.w3.org/2000/01/rdf-schema#Literal> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=title&char=1931,1951>
        a                     nif:Title ;
        nif:anchorOf          "Clinical development" ;
        nif:beginIndex        "1931"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1951"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=771,785>
        a                     nif:Word ;
        nif:anchorOf          "phosphodiester" ;
        nif:beginIndex        "771"^^xsd:nonNegativeInteger ;
        nif:endIndex          "785"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Phosphodiester> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152>
        a                     nif:Paragraph ;
        nif:beginIndex        "632"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1152"^^xsd:nonNegativeInteger ;
        nif:nextParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1153,1177> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=136,149>
        a                     nif:Phrase ;
        nif:anchorOf          "messenger RNA" ;
        nif:beginIndex        "136"^^xsd:nonNegativeInteger ;
        nif:endIndex          "149"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=0,247> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Messenger_RNA> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1892,1929>
        a                     nif:Paragraph ;
        nif:beginIndex        "1892"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1929"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=0,247>
        a                     nif:Paragraph ;
        nif:beginIndex        "0"^^xsd:nonNegativeInteger ;
        nif:endIndex          "247"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=0,247> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=999,1008>
        a                     nif:Word ;
        nif:anchorOf          "nucleases" ;
        nif:beginIndex        "999"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1008"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Nucleases> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=2542,2583>
        a                     nif:Phrase ;
        nif:anchorOf          "Phase 3 results from Isis Pharmaceuticals" ;
        nif:beginIndex        "2542"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2583"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=0,247> ;
        itsrdf:taIdentRef     <http://www.isispharm.com/Pipeline/Therapeutic-Areas/Cardiovascular.htm#Mipomersen> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=545,610>
        a                     nif:Paragraph ;
        nif:beginIndex        "545"^^xsd:nonNegativeInteger ;
        nif:endIndex          "610"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=261,544>
        a                     nif:Paragraph ;
        nif:beginIndex        "261"^^xsd:nonNegativeInteger ;
        nif:endIndex          "544"^^xsd:nonNegativeInteger ;
        nif:nextParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=545,610> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2464,2557>
        a                     nif:Section ;
        nif:beginIndex        "2464"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2557"^^xsd:nonNegativeInteger ;
        nif:hasParagraph      <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2479,2557> ;
        nif:lastParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2479,2557> ;
        nif:previousSection   <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2451,2462> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        skos:notation         "5"^^<http://www.w3.org/2000/01/rdf-schema#Literal> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=294,334>
        a                     nif:Phrase ;
        nif:anchorOf          "homozygous familial hypercholesterolemia" ;
        nif:beginIndex        "294"^^xsd:nonNegativeInteger ;
        nif:endIndex          "334"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=261,544> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Familial_hypercholesterolemia> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=472,477>
        a                     nif:Word ;
        nif:anchorOf          "liver" ;
        nif:beginIndex        "472"^^xsd:nonNegativeInteger ;
        nif:endIndex          "477"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=261,544> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Liver> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=1929,1945>
        a                     nif:Word ;
        nif:anchorOf          "phosphorothioate" ;
        nif:beginIndex        "1929"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1945"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=0,247> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Thiophosphate> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1178,1891>
        a                     nif:Paragraph ;
        nif:beginIndex        "1178"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1891"^^xsd:nonNegativeInteger ;
        nif:nextParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1892,1929> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=2030,2050>
        a                     nif:Phrase ;
        nif:anchorOf          "ISIS Pharmaceuticals" ;
        nif:beginIndex        "2030"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2050"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1952,2211> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Isis_Pharmaceuticals> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=670,695>
        a                     nif:Phrase ;
        nif:anchorOf          "antisense oligonucleotide" ;
        nif:beginIndex        "670"^^xsd:nonNegativeInteger ;
        nif:endIndex          "695"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Antisense_oligonucleotide> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=97,118>
        a                     nif:Phrase ;
        nif:anchorOf          "antisense therapeutic" ;
        nif:beginIndex        "97"^^xsd:nonNegativeInteger ;
        nif:endIndex          "118"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=0,247> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Antisense_therapy> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=729,745>
        a                     nif:Word ;
        nif:anchorOf          "phosphorothioate" ;
        nif:beginIndex        "729"^^xsd:nonNegativeInteger ;
        nif:endIndex          "745"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Thiophosphate> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=title&char=249,260>
        a                     nif:Title ;
        nif:anchorOf          "Indications" ;
        nif:beginIndex        "249"^^xsd:nonNegativeInteger ;
        nif:endIndex          "260"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1153,1177>
        a                     nif:Paragraph ;
        nif:beginIndex        "1153"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1177"^^xsd:nonNegativeInteger ;
        nif:nextParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1178,1891> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449>
        a                     nif:Section ;
        nif:beginIndex        "1931"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2449"^^xsd:nonNegativeInteger ;
        nif:hasParagraph      <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1952,2211> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2212,2449> ;
        nif:lastParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2212,2449> ;
        nif:nextSection       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=2451,2462> ;
        nif:previousSection   <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        skos:notation         "3"^^<http://www.w3.org/2000/01/rdf-schema#Literal> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=798,801>
        a                     nif:Word ;
        nif:anchorOf          "RNA" ;
        nif:beginIndex        "798"^^xsd:nonNegativeInteger ;
        nif:endIndex          "801"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Ribonucleic_acid> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=154,170>
        a                     nif:Phrase ;
        nif:anchorOf          "apolipoprotein B" ;
        nif:beginIndex        "154"^^xsd:nonNegativeInteger ;
        nif:endIndex          "170"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=0,247> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Apolipoprotein_B> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=phrase&char=2508,2538>
        a                     nif:Phrase ;
        nif:anchorOf          "Phase III trials of Mipomersen" ;
        nif:beginIndex        "2508"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2538"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2479,2557> ;
        itsrdf:taIdentRef     <http://clinicaltrials.gov/ct2/results?term=Mipomersen&phase=2> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=612,1929>
        a                     nif:Section ;
        nif:beginIndex        "612"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1929"^^xsd:nonNegativeInteger ;
        nif:hasParagraph      <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1178,1891> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1892,1929> , <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1153,1177> ;
        nif:lastParagraph     <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=1892,1929> ;
        nif:nextSection       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449> ;
        nif:previousSection   <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=249,610> ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        skos:notation         "2"^^<http://www.w3.org/2000/01/rdf-schema#Literal> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=1077,1082>
        a                     nif:Word ;
        nif:anchorOf          "liver" ;
        nif:beginIndex        "1077"^^xsd:nonNegativeInteger ;
        nif:endIndex          "1082"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Liver> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=2212,2449>
        a                     nif:Paragraph ;
        nif:beginIndex        "2212"^^xsd:nonNegativeInteger ;
        nif:endIndex          "2449"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=section&char=1931,2449> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=806,809>
        a                     nif:Word ;
        nif:anchorOf          "DNA" ;
        nif:beginIndex        "806"^^xsd:nonNegativeInteger ;
        nif:endIndex          "809"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Deoxyribonucleic_acid> .

<http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=word&char=835,846>
        a                     nif:Word ;
        nif:anchorOf          "deoxyribose" ;
        nif:beginIndex        "835"^^xsd:nonNegativeInteger ;
        nif:endIndex          "846"^^xsd:nonNegativeInteger ;
        nif:referenceContext  <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=context> ;
        nif:superString       <http://nif.dbpedia.org/wiki/en/Mipomersen?dbpv=2016-10&nif=paragraph&char=632,1152> ;
        itsrdf:taIdentRef     <http://nif.dbpedia.org/wiki/en/Deoxyribose> .